What great rune is the best?

Could you please enlighten me on the subject of runes? Specifically, I'm curious about which great rune stands out as the most powerful or advantageous among all the options available? Could you explain what characteristics or benefits this particular rune possesses that makes it superior to the others? Additionally, how does it compare to other runes in terms of its impact on gameplay or strategic value? I'm eager to understand why this rune is considered the best.