What are bitcoin runes & how do I manage them?

Could you elaborate on the concept of "bitcoin runes" and provide guidance on how one might manage them? Given the nature of cryptocurrencies, I'm wondering if this refers to a specific technical aspect, such as private keys or cryptographic signatures, or if it's a more metaphorical term referring to strategies for managing Bitcoin holdings. If it's the latter, I'd appreciate insights into effective practices for safekeeping Bitcoin, such as using hardware wallets, maintaining multiple addresses, and adopting secure storage and transaction methods. Clarifying this terminology and offering management tips would be greatly appreciated.