Cryptocurrency Q&A
How is STAT1 regulated?
How is STAT1 regulated?
Giuseppe
Wed Oct 30 2024
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5 answers
1024
I'm interested in understanding the regulation of STAT1. Could you explain how it is controlled or modulated in the cellular context?
5 answers
Isabella
Fri Nov 01 2024
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Rosalia
Fri Nov 01 2024
STAT1 activation is a temporary process that undergoes rigorous regulation.
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EthereumElite
Fri Nov 01 2024
The activation of STAT1 is initiated by phosphorylation on tyrosine 701 (Y701). This process is catalyzed by Janus kinases (JAKs), which are enzymes that play a crucial role in signal transduction.
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OpalSolitude
Fri Nov 01 2024
Once phosphorylated, STAT1 undergoes a conformational change that allows it to dimerize and form active STAT1 dimers.
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Elena
Fri Nov 01 2024
These dimers then translocate to the nucleus, where they bind to specific DNA sequences and regulate gene expression.
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