Cryptocurrency Q&A
What interactions does STAT1 have?
What interactions does STAT1 have?
AzurePulseStar
Thu Oct 31 2024
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5 answers
1187
I'm interested in understanding the interactions of STAT1. Could you please elaborate on the various interactions it has?
5 answers
Martina
Sat Nov 02 2024
Following phosphorylation, STAT1 detaches from the receptor. This dissociation allows STAT1 to undergo further structural changes necessary for its role in signaling.
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henry_taylor_architect
Sat Nov 02 2024
Once dissociated, STAT1 undergoes dimerization. This process occurs through reciprocal SH2-phosphotyrosine interactions, forming a stable dimer that is ready for downstream signaling.
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Lorenzo
Sat Nov 02 2024
STAT1 interacts with phosphorylated Tyr-440 via its SH2 domain. This binding is crucial for the subsequent phosphorylation process.
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Elena
Sat Nov 02 2024
The dimerized STAT1 then binds to IFN-inducible promoters. This binding is specific and crucial for the regulation of interferon-responsive genes.
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Margherita
Sat Nov 02 2024
When STAT1 binds to phosphorylated Tyr-440, its Tyr-701 residue becomes available for phosphorylation by JAKs. This phosphorylation event is essential for STAT1's activation.
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