I'm interested in understanding the function of STAT1 gene. Specifically, I want to know which genes are activated by STAT1.
6 answers
ShintoSanctuary
Sat Nov 02 2024
STAT1 possesses the ability to interact with phosphorylated Tyr-440 via its SH2 domain.
Lorenzo
Fri Nov 01 2024
STAT1 then forms dimers through reciprocal SH2-phosphotyrosine interactions.
GyeongjuGloryDaysFestival
Fri Nov 01 2024
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CryptoAlly
Fri Nov 01 2024
This interaction facilitates the phosphorylation of STAT1's Tyr-701 residue by JAKs.
DigitalBaron
Fri Nov 01 2024
Once phosphorylated, STAT1 undergoes a conformational change.