I'm interested in learning about STAT1 and its potential role in oncogenesis. Specifically, I want to know if STAT1 is considered an oncogene.
5 answers
GangnamGlitzGlamourGloryDays
Fri Nov 08 2024
Depending on the circumstances, it can function either as a tumor suppressor or an oncoprotein.
EchoSeeker
Fri Nov 08 2024
STAT1 exhibits dual characteristics in the context of human cancer.
CryptoNinja
Thu Nov 07 2024
The tumor-suppressive aspect of STAT1 is supported by specific scientific findings.
Giuseppe
Thu Nov 07 2024
Research has shown that when STAT1 is reconstituted in murine fibrosarcoma cells that are deficient in STAT1, there is a significant reduction in tumorigenicity and metastasis.
Giuseppe
Thu Nov 07 2024
This effect was observed in nude mice, which are commonly used in cancer research due to their lack of a thymus and therefore an impaired immune system.