I'm trying to understand the activation process of STAT1. I want to know what factors or molecules can trigger the activation of STAT1 in a biological context.
7 answers
Nicola
Sat Nov 02 2024
Research has shown that STAT1 is a key mediator in the activation of IFN-γ-induced inflammatory activities.
Margherita
Sat Nov 02 2024
IFN-α also activates the expression of IFN-γ–STAT1–dependent genes, albeit to a lesser extent compared to IFN-γ.
HanjiArtistryCraftsmanshipMasterpiece
Sat Nov 02 2024
When macrophages are primed with IFN-γ, they exhibit a stronger activation of STAT1 and subsequent STAT1-dependent genes.
Claudio
Sat Nov 02 2024
This priming effect not only enhances the response to IFN-γ itself but also to other cytokines like IL-6 and IL-10.
Giulia
Sat Nov 02 2024
STAT1 plays a pivotal role in regulating the inflammatory responses triggered by IFN-γ.