Cryptocurrency Q&A What activates STAT1?

What activates STAT1?

Riccardo Riccardo Thu Oct 31 2024 | 7 answers 1782
I'm trying to understand the activation process of STAT1. I want to know what factors or molecules can trigger the activation of STAT1 in a biological context. What activates STAT1?

7 answers

Nicola Nicola Sat Nov 02 2024
Research has shown that STAT1 is a key mediator in the activation of IFN-γ-induced inflammatory activities.

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Margherita Margherita Sat Nov 02 2024
IFN-α also activates the expression of IFN-γ–STAT1–dependent genes, albeit to a lesser extent compared to IFN-γ.

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HanjiArtistryCraftsmanshipMasterpiece HanjiArtistryCraftsmanshipMasterpiece Sat Nov 02 2024
When macrophages are primed with IFN-γ, they exhibit a stronger activation of STAT1 and subsequent STAT1-dependent genes.

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Claudio Claudio Sat Nov 02 2024
This priming effect not only enhances the response to IFN-γ itself but also to other cytokines like IL-6 and IL-10.

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Giulia Giulia Sat Nov 02 2024
STAT1 plays a pivotal role in regulating the inflammatory responses triggered by IFN-γ.

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