What happens when Akt is inhibited?

Could you elaborate, please, on what occurs specifically when Akt, that critical signaling protein, is prevented from functioning as intended? What sort of biochemical cascade or cellular reactions do we observe in this scenario? Would the absence of Akt's regulatory activities result in immediate cellular malfunction, or does the process play out gradually over time? Moreover, what types of external agents or internal cellular conditions could trigger the inhibition of Akt, and how might such inhibitions manifest in terms of physiological outcomes? Understanding these intricacies would greatly enhance our comprehension of Akt's role in cellular homeostasis and disease pathogenesis.