Could you please elaborate on how Akt prevents apoptosis? I'm particularly interested in understanding the molecular mechanisms involved in this process. Could you break down the steps Akt takes to inhibit apoptosis and explain the role of its downstream effectors? Additionally, how does Akt's activation affect cell survival and proliferation? Is there any specific signaling pathway or protein interaction that Akt utilizes to achieve this anti-apoptotic effect? I'm keen to gain a deeper understanding of this topic.
7 answers
Sara
Mon May 27 2024
In addition to phosphorylating BAD, AKT also targets the Serl84 site of Bax, another protein involved in apoptosis. Bax is known to have a pro-apoptotic effect, promoting cell death.
SumoPower
Mon May 27 2024
AKT, upon activation, initiates a cascade of biochemical reactions within the cell. One of its primary targets is the Bcl-2-associated death promoter (BAD), a protein that plays a crucial role in apoptosis.
SsangyongSpiritedStrengthCourageBravery
Mon May 27 2024
AKT's phosphorylation of Bax at the Serl84 site inhibits its apoptotic activity. This modulation of Bax's function helps to maintain cellular homeostasis and prevent unnecessary cell death.
Elena
Mon May 27 2024
AKT phosphorylates BAD at the Serl36 site, a specific amino acid sequence that undergoes chemical modification. This phosphorylation event triggers a conformational change in BAD.
benjamin_cole_nurse
Mon May 27 2024
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