Cryptocurrency Q&A
How does Akt become activated?
How does Akt become activated?
CryptoDynasty
Sat May 25 2024
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5 answers
929
Could you please elaborate on the process of Akt activation? I'm curious to know the specific mechanisms involved in triggering its activity. Could you describe the steps that lead to Akt becoming activated? Also, are there any specific conditions or factors that need to be present for Akt activation to occur? It would be helpful if you could provide a detailed explanation of this process.
5 answers
Stefano
Mon May 27 2024
The phosphorylation of T308 is catalyzed by PDK1, an enzyme that recognizes and modifies AKT at this specific site. Similarly, mTORC2, another enzyme complex, is responsible for phosphorylating S473.
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KimchiQueenCharm
Mon May 27 2024
These phosphorylations, in combination, lead to the full activation of AKT. This activated state allows AKT to carry out its downstream functions, including regulating cell growth, survival, and metabolism.
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CryptoEnthusiast
Mon May 27 2024
Cytosolic AKT, initially inactive, undergoes a crucial transformation when it is recruited to the membrane. This recruitment is facilitated by the PH domain's affinity for PIP3, a phospholipid crucial for AKT activation.
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Martino
Mon May 27 2024
However, the activation of AKT is tightly controlled and must be terminated to maintain cellular homeostasis. This termination is achieved by enzymes like PTEN, a PIP3 phosphatase that depletes PIP3 levels, and protein phosphatases such as PP2A and PHLPP.
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Andrea
Mon May 27 2024
Once at the membrane, AKT interacts with PIP3, initiating a cascade of biochemical reactions. These reactions include the phosphorylation of specific amino acid residues on AKT, namely T308 and S473.
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