Cryptocurrency Q&A
How does Akt stimulate cell growth?
How does Akt stimulate cell growth?
SsangyongSpirited
Sun May 26 2024
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7 answers
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Could you please elaborate on the mechanisms behind Akt stimulating cell growth? I'm curious to understand how Akt activates its downstream targets to promote cellular proliferation. Additionally, I'm interested in knowing if Akt's role in cell growth is specific to certain types of cells or if it's a more general phenomenon across various cell types. Could you also explain any potential regulatory mechanisms that might modulate Akt's activity in cell growth? Thank you for your insights.
7 answers
benjamin_stokes_astronomer
Tue May 28 2024
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Claudio
Tue May 28 2024
Growth-factor-mediated Akt activation plays a pivotal role in cellular processes. This activation triggers a cascade of events that lead to the transcription of c-Myc, a crucial factor in cell cycle progression.
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Elena
Mon May 27 2024
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Enrico
Mon May 27 2024
c-Myc, as a strong promoter, induces cells to exit the quiescent G0 phase. This transition is achieved by upregulating the expression of D-type cyclins, essential for cell cycle progression.
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Silvia
Mon May 27 2024
Concurrently, c-Myc suppresses the expression of negative cell cycle regulators. These include proteins like p21Cip1 and p27Kip1, which normally function to restrain cell growth and division.
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