Could you kindly elaborate on the mechanism by which Akt regulates the cell cycle? I'm particularly interested in understanding how Akt influences the various stages of the cycle, including how it might activate or deactivate certain proteins that are critical for cell growth and division. Additionally, I'd appreciate it if you could provide insights into how Akt's regulation might be altered in pathological conditions, such as cancer, and how this might contribute to abnormal cell proliferation. Thank you for your time and expertise in addressing this question.
6 answers
HanRiverWave
Mon May 27 2024
The direct phosphorylation of target proteins by Akt kinase can alter their activity, stability, or subcellular localization, thereby influencing their role in cell cycle progression.
Carlo
Mon May 27 2024
Indirect regulation of protein expression levels by Akt kinase, on the other hand, can occur through the modulation of transcription or translation processes.
Carolina
Mon May 27 2024
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Stefano
Mon May 27 2024
Akt kinase is a critical regulator of cell cycle progression, particularly at the G1/S and G2/M transitions. It exerts its influence on these vital stages of cell division by modulating the function of numerous substrates.
ethan_lewis_journalist
Mon May 27 2024
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