What does a high AChR antibody level mean?

If you have a higher concentration of AChR antibody, it means that you may have MG. Even with a normal level, it's still possible that you have MG. Most people with MG who have general muscle weakness have AChR antibody. In addition, about half of people with MG affecting the eyes will have the antibody. How is this test done?

What is the percentage loss of acetylcholine receptor (AChR)?

AChR (muscle) modulating antibodies: 0-20% (reported as percentage loss of AChR) An image depicting an AChR can be seen below. Acetylcholine receptor. Note 5 subunits, each with 4 membrane-spanning domains forming a rosette with a central opening. The central opening acts as an ion channel.

What is acetylcholine receptor?

An acetylcholine receptor (abbreviated AChR) is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter . Like other transmembrane receptors, acetylcholine receptors are classified according to their "pharmacology," or according to their relative affinities and sensitivities to different molecules.

Why do I need a repeat AChR antibody test?

In patients with known myasthenia gravis, repeat AChR antibody tests may be done to monitor response to therapy, to guide disease management, or to assess the risk of AChR antibody transfer from a mother to her unborn child. An AChR antibody test may sometimes be ordered when a thymoma is detected during an imaging scan.