Claudio
Fri Nov 01 2024
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0 answers
0
What is STAT1 gain of function?
I'm interested in understanding STAT1 gain of function. Could you please explain what it is and how it affects the normal functioning of STAT1 in the cellular context?
Raffaele
Fri Nov 01 2024
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7 answers
1014
What is STAT1 type 1 diabetes?
I have heard about STAT1 type 1 diabetes and I am curious to learn more about it. Could someone please explain what STAT1 type 1 diabetes is?
CryptoLordGuard
Fri Nov 01 2024
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5 answers
1248
What cytokines activate STAT1?
I'm interested in understanding which cytokines can activate STAT1. I'm looking for specific cytokines that have this capability.
Emanuele
Fri Nov 01 2024
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5 answers
1053
What are the target genes for STAT1?
I'm interested in understanding the target genes that are specifically regulated or influenced by STAT1. I want to know which genes are directly affected by the activity of STAT1.
Daniele
Fri Nov 01 2024
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5 answers
1225
What are JAK inhibitors for STAT1 GOF?
JAK inhibitors are drugs that target the JAK-STAT signaling pathway, which is involved in various immune and inflammatory responses. In the context of STAT1 GOF (gain-of-function) mutations, JAK inhibitors such as ruxolitinib have been shown to effectively reverse immune dysregulation by reducing hyperphosphorylation of STAT1 and preventing excessive T-cell apoptosis. This suggests that JAK inhibitors could be a potential therapeutic option for patients with STAT1 GOF-related conditions.
